Pure red cell aplasia with thymoma: Evidence of T-cell clonal disorder
نویسندگان
چکیده
منابع مشابه
Pure red cell aplasia and associated thymoma
Pure red cell aplasia is a rare cause of anemia, caused by an absence of red blood cell precursors in the bone marrow. It is usually a paraneoplastic syndrome, associated most commonly with large-cell granular lymphocyte leukemia but also thymoma. For patients who present both pure red cell aplasia and thymoma, thymectomy leads to an initial remission of the aplasia in 30% of cases. However, su...
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We here describe a case involving a 67-yearold female patient who was referred to our hospital due to severe anemia (hemoglobin, 5.0 g/dL), thrombocytopenia (platelet count, 0.6 × 104/μL), and a mediastinal shadow with calcification noted on X-ray. On admission, an anterior mediastinal tumor was detected, and bone marrow biopsy revealed few megakaryocytes and severely reduced numbers of erythro...
متن کاملPure red cell aplasia associated with malignant thymoma, myasthenia gravis, polyclonal large granular lymphocytosis and clonal thymic T cell expansion.
A case with the triad of pure red cell aplasia (PRCA), myasthenia gravis, and malignant thymoma is reported. There was a clonal proliferation of T cells within the thymoma, as demonstrated by a T cell antigen receptor (TCR) delta chain gene rearrangement. However, despite a large granular lymphocytosis, clonality could not be shown in the peripheral blood either before or after thymectomy. Ther...
متن کاملThymoma associated with hypogammaglobulinaemia and pure red cell aplasia
Thymomas are neoplasias that begin in the thymus and develop in the anterior mediastinum. They are commonly associated with a variety of systemic and autoimmune disorders, such as pure red cell aplasia, hypogammaglobulinaemia, pancytopaenia, collagen diseases, and, most commonly, myasthenia gravis. The presence of inter-current infections, especially diarrhoea and pneumonia, in the presence of ...
متن کاملAcquired pure red cell aplasia.
Correspondence MEDICALTJOSRNAL 559 Acquired Pure Red Cell Aplasia SIR,-May we make the following observation about your article on acquired pure red cell aplasia and its treatment with steroids (6 April, p. 3) ? A pure red cell aplasia that responded to riboflavine or prednisone has been described in African adults and in children with marasmus and kwashiorkor.' In marasmus and kwashiorkor an e...
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ژورنال
عنوان ژورنال: American Journal of Hematology
سال: 1997
ISSN: 0361-8609,1096-8652
DOI: 10.1002/(sici)1096-8652(199704)54:4<324::aid-ajh12>3.0.co;2-b